Placental Alk Phosphatase (PLAP)

PLAP is a membrane-bound alkaline phosphatase with a molecular weight of 70KDa, present in normal placenta. It is also expressed in ovarian germ cell tumors, testis and extra-gonad germ cell tumors, including seminoma, gonadoblastoma, yolk sac tumor and choriocarcinoma. PLAP is mainly used in the diagnosis of gonadal germ cell tumors, testicular germ cell tumors and ovarian dysgerminoma.